We present an update on the molecular pathology of prostate cancer, including its molecular classification, key driver gene and other somatic alterations, as well as current concepts around biomarker testing, with an emphasis on information pertinent to the surgical pathologist for their daily practice and communications with clinicians. For in depth coverage of the molecular and clinical features of potential prostate cancer precursors, including high grade prostatic intraepithelial neoplasia, the readers are directed to recent publications.
Histopathology. 2026 Apr 07 [Epub ahead of print]
Fernanda Caramella Pereira, Angelo M De Marzo
Department of Pathology, Urology and Oncology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.