Squamous transformation of prostate adenocarcinoma is a rare resistance mechanism in patients with advanced prostate cancer that impacts both prognosis and treatment. Herein, we profile circulating chromatin in serial plasma samples collected from a patient with metastatic prostate cancer that experienced squamous transformation.
We detect dynamic changes in gene regulation from circulating chromatin reflecting the emergence of squamous differentiation, enabling non-invasive diagnosis and monitoring of this resistance phenotype, with potential therapeutic implications.
NPJ precision oncology. 2025 Jul 09*** epublish ***
Karl Semaan, Rashad Nawfal, John Canniff, Hunter Savignano, Ji-Heui Seo, Stephanie E Siegmund, Sarah J Wu, Julia K Rotow, Gwo-Shu Mary Lee, Razane El Hajj Chehade, Ze Zhang, Gunsagar S Gulati, Noa Phillips, Garyoung Gary Lee, Christopher A French, Michelle S Hirsch, Heather A Jacene, Atish D Choudhury, Toni K Choueiri, Matthew L Freedman, Sylvan C Baca, Jacob E Berchuck
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Department of Imaging, Dana-Farber Cancer Institute, Boston, MA, USA., Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. ., Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. .
PubMed http://www.ncbi.nlm.nih.gov/pubmed/40634667