Prostate biopsy prior to radical treatment for prostate cancer is a common practice worldwide to allow diagnosis, prognostication, and treatment planning. However, recent advances in prostate multiparametric magnetic resonance imaging (mpMRI) and prostate-specific membrane antigen (PSMA)-positron emission tomography (PET) have made the possibility of a "biopsy-free" radical prostatectomy, without prior biopsy, closer to reality than before. The biopsy-free approach serves to avoid investigation-related morbidity, health care resources, and time to definitive treatment, but is not without risk. Here we review the literature surrounding the rationale, limitations, and current data.
Prostate international. 2025 Mar 18 [Epub]
Arya Bahadori, Jessie Woods, Lance Yuan, Louise Emmett, John Yaxley, Matthew J Roberts
Department of Urology, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia., Department of Theranostics and Nuclear Medicine, St Vincent's Hospital, Sydney, Australia.