Detection of MRI-Invisible Disease Using PSMA PET/CT in a Patient Considering Focal Therapy.

Patient selection for focal therapy (FT) of prostate cancer requires the assessment of MRI and biopsy results. However, there is currently little guidance for the utility of PSMA PET/CT in FT planning. We describe the case of a man originally considered an ideal candidate for FT based on biopsy and MRI who was found to have a contralateral lesion-harboring cancer detected only on PSMA PET/CT. Trial Registration: ClinicalTrials.gov identifier: NCT05852041.

Case reports in urology. 2025 Mar 26*** epublish ***

Jae Woong Jang, Aaron Abrams, Anugayathri Jawahar, Hatice Savas, Ximing J Yang, Vikas Mehta, Marina Schnauss, Edward M Schaeffer, Ridwan Alam, Ashley E Ross

Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Department of Radiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.