Treatment resistance remains a universal driver of lethal metastatic prostate cancer, associated with acquired genomic alterations and lineage transitions. Using a novel high-purity CTC isolation approach for CTC transcriptional profiling, we identified four lineage phenotypes differentially associated with prognosis in metastatic prostate cancer.
Cancer discovery. 2025 Apr 01 [Epub ahead of print]
Marina N Sharifi, Jamie M Sperger, Amy K Taylor, Katharine E Tippins, Shannon R Reese, Viridiana Carreno, Katherine R Kaufmann, Alex H Chang, Luke A Nunamaker, Charlotte Linebarger, Leilani Mora-Rodriguez, Jennifer L Schehr, Hannah M Krause, Kyle T Helzer, Matthew L Bootsma, Grace C Blitzer, John M Floberg, Christos E Kyriakopoulos, Hamid Emamekhoo, Elisabeth I Heath, Meghan Wells, Scott T Tagawa, Martin Sjöström, Atish D Choudhury, Menggang Yu, Andrew J Armstrong, Dana E Rathkopf, Himisha Beltran, Peter S Nelson, Felix Y Feng, Scott M Dehm, David Kosoff, Xiao X Wei, Rana R McKay, Shuang G Zhao, Joshua M Lang
Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin., Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin., Department of Human Oncology, University of Wisconsin-Madison, Madison, Wisconsin., Karmanos Cancer Institute, Wayne State University, Detroit, Michigan., Weill Cornell Medical College, New York, New York., Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California., Dana-Farber Cancer Institute, Boston, Massachusetts., Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, Michigan., Duke Cancer Institute Center for Prostate and Urologic Cancer, Duke University, Durham, North Carolina., Division of Solid Tumor Oncology, Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center, New York, New York., Division of Human Biology, Fred Hutchinson Cancer Center, Seattle, Washington., Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota., Moores Cancer Center, University of California San Diego, La Jolla, California.