Radical Prostatectomy for Localized Prostate Cancer: 20-Year Oncological Outcomes from a German High-Volume Center - Beyond the Abstract

In this large-scale single-institutional retrospective analysis of 22,843 prostate cancer patients treated with radical prostatectomy between 1992 and 2017, we report the largest and most contemporary long-term oncological outcomes from Europe.

The primary outcome of interest was cancer-specific survival, with a median follow-up of 68 months. Preoperative risk-classification was performed according to the National Comprehensive Cancer Network risk groups of low, intermediate, high, and very high. In this regard, in low-risk patients, 20-years cancer-specific survival was 90.1%. In intermediate-risk patients, 20-years cancer-specific survival was 83.2%. In high/very high risk patients, 20-years cancer-specific survival was 69.6%/60.8%.

These findings highlight the very favorable outcomes after radical prostatectomy also in the very long term, also within Europe. However, since the present data is based on a single-armed, single-institutional approach, no comparison to other treatment modalities should be attempted and therefore, our report should be interpreted with caution.

Written by: Christoph Würnschimmel, MD, Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, Hamburg, Germany

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