At Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST -IRCCS), a Cancer Centre in Romagna, we aim to classify PCa patients according to PSMA expression. Our research shows that PSMA increases as tumor grade (Gleason score) increases, and this finding could potentially be used by pathologists to classify tumors on the basis of cellular morphology alone. The tumors morphologically classified as Gleason pattern 3 showing high PSMA expression may be more aggressive. Thus, analyzing PSMA by immunohistochemistry could facilitate patient stratification. In particular, our study revealed lower PSMA expression in Gleason pattern 3 (Grade Group 1) compared to Gleason pattern 4 (Grade Group 2) or 5 (Grade Group 3), with a PSMA sensitivity of 84% and a specificity of 95%.
Moreover, given that the degree of uptake of 68 Ga-PSMA-11 in prostate cancer cells was found to correlate with PSMA expression, this biomarker may be useful for both therapeutic purposes and patient follow-up.
Written by: Dott.ssa Sara Bravaccini, PhD, Researcher, Laboratory of Biosciences, Cyto Histo Molecular Pathology, Scientific Institute of Romagna for the Study and the Treatment of Cancer ( IRST ) Srl IRCCS, Via Maroncelli, Meldola FC, Italy
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