The Seed and Soil Hypothesis Revisited - the Role of Tumor-Stroma Interactions in Metastasis to Different Organs

The fact that certain tumors exhibit a predilection for metastasis to specific organs has been recognized for well over a century now. An extensive body of clinical data and experimental research has confirmed Stephen Paget's original “seed and soil” hypothesis that proposed the organ-preference patterns of tumor metastasis are the product of favorable interactions between metastatic tumor cells (the “seed”) and their organ microenvironment (the “soil”). Indeed, many of first-line therapeutic regimens currently in use for the treatment of human cancer are designed to target cancer cells (such as chemotherapy) and also to modulate the tumor microenvironment (such as anti-angiogenic therapy). While some types of tumors are capable of forming metastases in virtually every organ in the body, the most frequent target organs of metastasis are bone, brain, liver, and the lung. In this review, we discuss how tumor-stromal interactions influence metastasis in each of these organs.

Int J Cancer. 2011 Jun 1;128(11):2527-35. doi: 10.1002/ijc.26031. Epub 2011 Mar 25.

Robert R. Langley and Isaiah J. Fidler

Author Information:
Isaiah J. Fidler, Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, TX USA

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.