Penile squamous cell carcinoma (PSCC) is a rare presentation in the United States and Europe, accounting for only 1% of male malignancies. Most commonly due to human papilloma virus (HPV), PSCC has an insidious onset, often ignored by patients until functional impairments are present. This report outlines an interesting presentation of penile squamous cell carcinoma while focusing on current developments in the prognosis and treatment of PSCC. We present the case of a 68-year-old male who presented with a 5 cm fungating mass of the glans penis after emergent care following a stroke. Visual inspection revealed a large mass of the glans penis which had completely obliterated the urethral meatus. A partial penectomy and urethrostomy were performed. Surgical excision revealed a unifocal moderately differentiated (G2) squamous cell carcinoma, with immunohistochemical staining demonstrating p16 positivity, consistent with HPV-associated etiology. This case highlights the importance of individualized treatment regimens and prognostic determination for optimal patient outcomes.
Journal of investigative medicine high impact case reports. 2026 Apr 13 [Epub]
Dominic M Collins, Alex Marvin Simpkins, John Diks, Dale Robertson
Joan C. Edwards School of Medicine, Huntington, WV, USA., Department of Pathology, Joan C. Edwards School of Medicine, Huntington, WV, USA., Department of Urology, Joan C. Edwards School of Medicine, Huntington, WV, USA.