Common gene rearrangements in prostate cancer - Abstract

Mark A. Rubin, Weill Cornell Medical College, New York, NY.

Christopher A. Maher, Center for Computational Medicine and Biology; Michigan Center for Translational Pathology; Arul M. Chinnaiyan, Michigan Center for Translational Pathology; Howard Hughes Medical Institute; Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI.



Prostate cancer is a common heterogeneous disease, and most patients diagnosed in the post prostate-specific antigen (PSA) era present with clinically localized disease, the majority of which do well regardless of treatment regimen undertaken. Overall, those with advanced prostate cancer at time of diagnosis do poorly after androgen withdrawal therapy. Understanding the biologic underpinning of prostate cancer is necessary to best determine the risk of disease progression and would be advantageous for the development of novel therapeutic approaches to impede or prevent disease. This review focuses on the recently identified common ETS and non-ETS gene rearrangements in prostate cancer. Although multiple molecular alterations have been detected in prostate cancer, a detailed understanding of gene fusion prostate cancer should help explain the clinical and biologic diversity, providing a rationale for a molecular subclassification of the disease.

Written by:
Rubin MA, Maher CA, Chinnaiyan AM.   Are you the author?

Reference: J Clin Oncol. 2011 Aug 22. Epub ahead of print.
doi: 10.1200/JCO.2011.35.1916

PubMed Abstract
PMID: 21859993 Prostate Cancer Section



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