Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts.

The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2020 Apr 02 [Epub ahead of print]

Joseph A Ioppolo, Rikki A Nezich, Kirsty L Richardson, Laurence Morandeau, Peter J Leedman, Roger I Price

Medical Technology and Physics Department, Sir Charles Gairdner Hospital, Hospital Ave, Nedlands, WA, 6009, Australia; School of Molecular and Life Sciences, Curtin University, Bentley, WA, 6102, Australia. Electronic address: ., Medical Technology and Physics Department, Sir Charles Gairdner Hospital, Hospital Ave, Nedlands, WA, 6009, Australia; Department of Physics, University of Western Australia, Crawley, WA, 6009, Australia., Harry Perkins Institute of Medical Research, QEII Medical Centre, 6 Verdun St, Nedlands, WA, 6009, Australia., Medical Technology and Physics Department, Sir Charles Gairdner Hospital, Hospital Ave, Nedlands, WA, 6009, Australia.

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