Benign prostatic hyperplasia treatment using plasmonic nanoparticles irradiated by laser in a rat model.

In the current study we have stimulated the efficacy of plasmonic nanoparticles (NPs) by laser hyperthermia to achieve a less invasive method for tumor photothermal therapy of benign prostatic hyperplasia (BPH).

The levels of apoptosis on induced BPH in rats were assessed after treatment and revealed and recorded by various assayed. Moreover, the expression of caspases was considered to demonstrate the apoptotic pathways due to laser induced plasmonic NPs.

In the Laser + NPs group prostate size of induced BPH decreased. Laser + NPs also decreased prostate specific antigen in comparison with the BPH groups. Furthermore, Laser + NPs attenuated BPH histopathologic indices in the rats. Laser + NPs induced apoptosis in prostatic epithelial cells via caspase-1 pathway.

Altogether, the approach and findings from this study can be applied to introduce the laser irritated NPs method as a novel and less invasive therapy for patients suffering from BPH.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Mar 31 [Epub ahead of print]

Omid Koohi Hosseinabadi, Mohammad Ali Behnam, Arezoo Khoradmehr, Farzin Emami, Zahra Sobhani, Amir Reza Dehghanian, Ali Dehghani Firoozabadi, Farhad Rahmanifar, Homeira Vafaei, Aryan-Dokht Tamadon, Nader Tanideh, Amin Tamadon

Laparoscopy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Central Research Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ., Nano-Opto-Electronic Research Center, Electrical and Electronics Engineering Department, Shiraz University of Technology, Shiraz, Iran. Electronic address: ., The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: ., Nano-Opto-Electronic Research Center, Electrical and Electronics Engineering Department, Shiraz University of Technology, Shiraz, Iran. Electronic address: ., Quality Control of Drug Products Department, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ., Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ., Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Electronic address: ., Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. Electronic address: ., Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ., The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: ., Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmacology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ., The Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Research Center, Bushehr University of Medical Sciences, Bushehr, Iran. Electronic address: .

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