Bone is one of the most preferential target site for cancer metastases, particularly for prostate, breast, kidney, lung and thyroid primary tumours. Indeed, numerous chemical signals and growth factors produced by the bone microenvironment constitute factors promoting cancer cell invasion and aggression. After reviewing the different theories proposed to provide mechanism for metastatic progression, we report on the gene expression profile of bone-seeking cancer cells. We also discuss the cross-talk between the bone microenvironment and invading cells, which impacts on the tumour actions on surrounding bone tissue. Lastly, we detail therapies for bone metastases. Due to poor prognosis for patients, the strategies mainly aim at reducing the impact of skeletal-related events on patients' quality of life. However, recent advances have led to a better understanding of molecular mechanisms underlying bone metastases progression, and therefore of novel therapeutic targets.
International journal of molecular sciences. 2018 Jan 04*** epublish ***
Annie Schmid-Alliana, Heidy Schmid-Antomarchi, Rasha Al-Sahlanee, Patricia Lagadec, Jean-Claude Scimeca, Elise Verron
Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur, Inserm, iBV, 06108 Nice, France. ., Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur, Inserm, iBV, 06108 Nice, France. ., Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur, Inserm, iBV, 06108 Nice, France. ., Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur, Inserm, iBV, 06108 Nice, France. ., Centre National de la Recherche Scientifique (CNRS), Université Côte d'Azur, Inserm, iBV, 06108 Nice, France., Regenerative Medicine and Skeleton. RMeS-Lab, INSERM UMR 1229, University of Nantes, 44000 Nantes, France. .