This study was conducted using the large, contemporary dataset of the National Cancer Data Base (NCDB) and included patients diagnosed with cT4bN0-3M0 bladder cancer with complete treatment records. Patients were divided into 5 treatment groups: CT alone, CRT, radical cystectomy (RC) (with/without CT/RT), other treatment (subtherapeutic RT with/without CT), or no treatment.
Of 896 total patients, 185 (20.6%) underwent CT alone, 80 (8.9%) CRT, 161 (18.9%) RC, 221 (24.7%) other treatments, and 249 (27.8%) observation. Observation yielded a median overall survival (OS) of 3.7 months, lower than CT alone (p<0.001). As compared to the latter, CRT was associated with higher OS (10.5 vs. 12.1 months, p=0.004). Radical cystectomy (RC)-based treatment displayed the numerically highest OS (14.2 months) and was statistically similar to CRT (p=0.676). Treatment with any modality independently predicted for superior OS over observation.
Written by: Waqar Haque, Vivek Verma, E Brian Butler, Bin S Teh
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1 Liberman D, Alasker A, Sun M, et al. Radical cystectomy for patients with pT4 urothelial carcinoma in a large population-based study. BJU Int 2011;107:905-911.
2 National Comprehensive Cancer Network. Bladder cancer. Version 4.2017. https://www.nccn.org/professionals/physician_gls/pdf/bladder.pdf Accessed May 19, 2017.