It is unknown whether marital status affects years of life lost (YLL) in metastatic urothelial carcinoma of the urinary bladder (mUCUB), according to sex and race/ethnicity.
Within SEER database (2004-2021), unmarried and married mUCUB patients aged 40-80 years were identified. Age- and sex-matched controls were generated (Social Security Administration life tables and Monte Carlo simulation). Years of life lost (YLL) were quantified, relative to age- and sex-matched simulated population controls.
In unmarried male mUCUB patients (n = 1,976), the distribution according to race/ethnicity was as follows: 1,546 Caucasians, 248 African Americans, 182 Hispanics. In unmarried female mUCUB patients (n = 998), the distribution according to race/ethnicity was as follows: 723 Caucasians, 161 African Americans, 114 Hispanics. In male mUCUB patients, unmarried status was more common in African Americans (OR 1.3, P < 0.05). YLL values in unmarried vs. married males relative to age- and sex- matched controls were 8.2 vs. 5.3 (Δ = 2.9) in Caucasians, 10.1 vs. 6.7 (Δ = 3.4) in African Americans and 8.2 vs. 7.3 (Δ = 0.9) in Hispanics. In Caucasian and African American mUCUB males, unmarried status independently predicted 1.2- fold higher CSM, but not in Hispanics. Conversely, unmarried status did not affect YLL values in females.
In males mUCUB patients, African American race/ethnicity predisposes to unmarried status. Caucasian and African American unmarried mUCUB males exhibited higher YLL values than controls. In those two groups, unmarried status independently predicts higher CSM. Conversely, in females no meaningful differences in YLL were recorded according to marital status.
Urologic oncology. 2026 Jun 06 [Epub ahead of print]
Michele Petix, Federico Polverino, Leonardo Quarta, Maximilian Filzmayer, Nick J Lee, Filippo Orlandi, Jordan A Goyal, Nicola Longo, Alberto Briganti, Felix Chun, Salvatore Micali, Shahrokh F Shariat, Andrea Marmiroli, Stefano Luzzago, Francesco Mistretta, Fred Saad, Gennaro Musi, Pierre I Karakiewicz
Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Università degli Studi di Milano, Milan, Italy; Department of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, Milan, Italy. Electronic address: ., Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Division of Experimental Oncology/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy., Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Department of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany., Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada., Cancer Prognostics and Health Outcomes Unit, Division of Urology, University of Montréal Health Center, Montréal, Québec, Canada; Department of Urology, AOU di Modena, University of Modena and Reggio Emilia, Modena, Italy., Department of Neurosciences, Science of Reproduction and Odontostomatology, University of Naples Federico II, Naples, Italy., Division of Experimental Oncology/Unit of Urology, URI, Urological Research Institute, IRCCS San Raffaele Scientific Institute, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy., Department of Urology, Goethe University Frankfurt, University Hospital, Frankfurt am Main, Germany., Department of Urology, AOU di Modena, University of Modena and Reggio Emilia, Modena, Italy., Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria; Department of Urology, Weill Cornell Medical College, New York, NY; Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan., Università degli Studi di Milano, Milan, Italy; Department of Urology, IEO European Institute of Oncology, IRCCS, Via Ripamonti 435, Milan, Italy.