Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer.

Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer development; however, its potential role and underlying mechanisms in the progression of BC remain unknown.

In this study, we evaluated Aurora kinase A (AURKA) expression in patient samples by performing gene expression profiling, and found that AURKA expression levels were significantly higher in BC tissues than in normal tissues. Increased AURKA in BC was strongly associated with stage and grade. Moreover, BC patients with elevated AURKA achieved poor overall survival rates. The experiments in vitro comprehensively validated the critical role of AURKA in promoting BC cell proliferation using the methods of gene overexpression and gene silencing. Furthermore, we proved that AURKA inhibitor MLN8237 arrested BC cell growth and induced apoptosis.

These findings implicate AURKA acting as an effective biomarker for BC detection and prognosis, as well as therapeutic target.

BMC systems biology. 2018 Dec 14*** epublish ***

Mengjie Guo, Sicheng Lu, Hongming Huang, Yaohui Wang, Mary Q Yang, Ye Yang, Zhimin Fan, Bin Jiang, Youping Deng

School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210023, China., Department of Hematology, Affiliated Hospital of Nantong University, Nantong, 226001, China., Department of Pathology, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, 210029, China., MidSouth Bioinformatics Center, Department of Information Science, George Washington Donaghey College of Engineering and Information Technology and Joint Bioinformatics Graduate Program, University of Arkansas at Little Rock and University of Arkansas for Medical Sciences, Little Rock, AR, 72204, USA., National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China., National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China. ., National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China. ., National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China. .

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