Novel protein signatures suggest progression to muscular invasiveness in bladder cancer

Patients with bladder cancer need frequent controls over long follow-up time due to high recurrence rate and risk of conversion to muscle invasive cancer with poor prognosis. We identified cancer-related molecular signatures in apparently healthy bladder in patients with subsequent muscular invasiveness during follow-up. Global proteomics of the normal tissue biopsies revealed specific proteome fingerprints in these patients prior to subsequent muscular invasiveness. In these presumed normal samples, we detected modulations of proteins previously associated with different cancer types. This study indicates that analyzing apparently healthy tissue of a cancer-invaded organ may suggest disease progression.

PloS one. 2018 Nov 12*** epublish ***

Magnus Berle, Luiza Ghila, Heidrun Vethe, Adeel Chaudhry, Hilde Garberg, Christian Beisland, Øystein Ariansen Haaland, Eystein Oveland, Ole Johan Halvorsen, Thomas Davidsson, Simona Chera

Department of Urology, Haukeland University Hospital, Bergen, Norway., Department of Clinical Science, University of Bergen, Bergen, Norway., Department of Biomedicine, Proteomic Unit, University of Bergen, Bergen, Norway., Department of Global Public Health and Primary Care, University of Bergen, Norway., Department of Pathology, Haukeland University Hospital, Bergen, Norway.