Methods: We performed a systematic literature review of UTI reduction secondary to topical estrogen utilization in postmenopausal female patients. The cost per UTI was determined based on published Medicare spending on UTI per beneficiary, weighted on reported likelihood of complicated and resistant infections. For a patient with recurrent infections, topical estrogen therapy reported on average can reduce infections from 5 to 0.5 to 2 times per person per year.
Results: At a calculated cost per UTI of $1222, the reduction in UTI spending can range between $3670 and $5499 per beneficiary per year. Per-beneficiary spending on topical estrogen therapies was $1013 on average ($578-$1445) in 2020. After including the cost of the therapy, overall cost savings for topical estrogen therapies were $1226 to $4888 annually per patient.
Conclusions: Topical estrogens are a cost-conscious way to improve the burden of UTI on postmenopausal women with the potential for billions of dollars in Medicare savings. System-wide efforts should be made to have these therapies available as prophylaxis for postmenopausal patients and to ensure they are affordable for patients.
Charlotte Goldman Houston,1 William S. Azar,1 Sean Shenghsiu Huang,2 Rachel Rubin,1 C. Scott Dorris,3 and Rachael D. Sussman1
- Department of Urology, Georgetown University, Washington, District of Columbia
- Department of Health Management and Policy, Georgetown University, Washington, District of Columbia
- Dahlgren Medical Library, Georgetown University Medical Center, Washington, District of Columbia