Diagram illustrating interventional treatment approaches for urethral stricture, emphasizing urothelial integrity in preventing stricture recurrence. It compares procedures such as balloon dilatation and urethrotomy which leave the sub-urothelium exposed to urine leading to inflammation to that of procedures such as BEES-HAUS in which transplanted buccal mucosal cells and in BHES-HAUS transplanted buccal tissue bits, both mixed with Festigel, engraft and restore the urothelial integrity. BEES-HAUS involves a two-week in vitro culture, while BHES-HAUS processes tissue in the operating room in single sitting. Both methods aim for effective urethral treatment using autologous buccal mucosal epithelium.Diagram illustrating interventional treatment approaches for urethral stricture, emphasizing urothelial integrity in preventing stricture recurrence. It compares procedures such as balloon dilatation and urethrotomy which leave the sub-urothelium exposed to urine leading to inflammation to that of procedures such as BEES-HAUS in which transplanted buccal mucosal cells and in BHES-HAUS transplanted buccal tissue bits, both mixed with Festigel, engraft and restore the urothelial integrity. BEES-HAUS involves a two-week in vitro culture, while BHES-HAUS processes tissue in the operating room in single sitting. Both methods aim for effective urethral treatment using autologous buccal mucosal epithelium.
Frontiers in bioengineering and biotechnology. 2025 Nov 27*** epublish ***
Akio Horiguchi, Surya Prakash Vaddi, Senthilkumar Rajappa, Senthilkumar Preethy, Samuel J K Abraham
Division of Reconstruction, Center for Trauma, Burn and Tactical Medicine, National Defense Medical College Hospital, Tokorozawa/Saitama, Japan., Department of Urology, Surya Kidney Centre, Hyderabad, India., Antony- Xavier Interdisciplinary Scholastics (AXIS), GN Corporation Co. Ltd., Kofu, Japan., The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai, Tamil Nadu, India.