To assess effectiveness and durability of Solifenacin (SS) versus tibial nerve stimulation (PTNS) versus combination therapy (PTNS + SS) in women with overactive bladder syndrome (OAB).
105 women with OAB were divided randomly into three groups of 35 patients each. In group A women received SS, in group B women underwent PTNS, in group C women underwent combination of PTNS + SS. Improvements in OAB symptoms were assessed with OABSS questionnaire; patients' quality of life was assessed with OAB-q SF questionnaire. Evaluation of effectiveness of treatments was performed with PGI-I questionnaire. OABSS and PGI-I were also assessed monthly for ten months.
All treatments were effective on symptoms. PTNS showed a greater effectiveness than SS, but PTNS + SS was more effective than SS and PTNS. Furthermore, PTNS + SS showed a greater duration of effectiveness than PTNS and SS.
Combination of PTNS with SS showed more effectiveness and more durability than PTNS and SS alone.
International braz j urol : official journal of the Brazilian Society of Urology. 2017 Oct 24 [Epub ahead of print]
Carlo Vecchioli-Scaldazza, Carolina Morosetti
Division of Urogynecology, ASUR, Jesi, Italy., Clinical Pathology, ASUR, Jesi, Italy.