Efficacy and safety of combinations of mirabegron and solifenacin compared with monotherapy and placebo in patients with overactive bladder (SYNERGY study)

Overactive bladder (OAB) syndrome is characterized by urinary urgency, with or without urgency urinary incontinence, usually accompanied by increased daytime frequency and nocturia, in the absence of urinary tract infection (UTI) or other obvious pathology [1].

Urgency urinary incontinence is present in approximately one-third of cases [2], but is not a prerequisite. However, of all the OAB symptoms, it has the greatest impact on quality of life (QoL) [3, 4], and is associated with significantly lower productivity and higher healthcare resource utilization [5]. This article is protected by copyright. All rights reserved.

BJU international. 2017 Apr 18 [Epub ahead of print]

Sender Herschorn, Christopher R Chapple, Paul Abrams, Salvador Arlandis, David Mitcheson, Kyu-Sung Lee, Arwin Ridder, Matthias Stoelzel, Asha Paireddy, Rob van Maanen, Dudley Robinson

Department of Surgery/Urology, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada., Department of Urology, Royal Hallamshire Hospital, Sheffield, UK., Bristol Urological Institute, Southmead Hospital, Bristol, UK., Hospital Universitario La Fé, Valencia, Spain., St. Elizabeth's Medical Center, Brighton, MA, USA., Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Astellas Pharma Global Development, Leiden, The Netherlands., Kings College Hospital, London, UK.