The objective of this multicenter, cross-sectional study was to investigate the relationship of nocturnal polyuria in patients with common lifestyle-related diseases and overactive bladder (OAB), with special attention to hypertension.
After baseline assessment, patients recorded their 24-hour urinary frequency/volume, blood pressure, and heart rate for 3 days, and were stratified into 4 groups based on mean blood pressure (no hypertension, controllable, untreated, and uncontrolled hypertension).
Eligible patients (n=2,353; urinary urgency ≥once/week, ≥1 nocturnal toilet visit) were enrolled from 543 sites in Japan. Of these, complete data including the 24-hour frequency volume chart was collected from 1,271 patients. Multivariable analyses showed a statistically significant association of nocturnal polyuria with increasing age (Odds ratio [OR] [95% CI]: 1.04 [1.02, 1.05], p<0.001), gender (OR [95% CI]: 0.75 [0.59, 0.96] for women vs men; p=0.02), and hypertension (OR [95% CI]: 1.10 [0.83, 1.46], 2.62 [1.55, 4.45], 1.15 [0.81, 1.62], for controllable, untreated, and uncontrolled hypertension vs no hypertension, respectively, p=0.005). However, when assessed separately for men and women, hypertension and heart rate were significantly associated with nocturnal polyuria in women alone (p=0.01 and 0.03, respectively). Lower urinary tract symptoms suggestive of benign prostatic hyperplasia were significantly associated with nocturnal polyuria in men alone (p<0.001).
The current study demonstrated that nocturnal polyuria was significantly associated with age, men, and untreated hypertension in patients with lifestyle-related diseases and OAB, with the association between hypertension and nocturnal polyuria significant in women alone.
The Journal of urology. 2016 Aug 23 [Epub ahead of print]
Osamu Yokoyama, Osamu Nishizawa, Yukio Homma, Masayuki Takeda, Momokazu Gotoh, Hidehiro Kakizaki, Hironobu Akino, Koichi Hayashi, Koji Yonemoto, OASIS project group
Department of Urology, Faculty of Medical Science, University of Fukui, Fukui, Japan. Electronic address: ., North Alps Medical Center Azumi Hospital, Kitaazumi, Nagano, Japan., Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan., Department of Urology, Nagoya University Graduate School of Medicine, Aichi, Japan., Department of Renal and Urologic Surgery, Asahikawa Medical University, Asahikawa, Japan., Department of Urology, Faculty of Medical Science, University of Fukui, Japan., Tokyo Dental College Ichikawa General Hospital, Japan., Biostatistics Center, Kurume University, Kurume, Japan.