The Clinical and Urodynamic Results of Percutaneous Posterior Tibial Nerve Stimulation on Neurogenic Detrusor Overactivity in Patients with Parkinson's Disease

To investigate the 12 weeks effect of percutaneous posterior tibial nerve stimulation (PTNS) treatment on urodynamic and clinical findings in the Parkinson's disease (PD) patients with neurogenic detrusor overactivity (NDO).

A total of 47 PD patients with NDO were enrolled in the study. Urodynamic studies before and after 12 weeks PTNS treatment were performed. Questionnaire Short Form (ICIQ-SF), Overactive Bladder Questionnaire (OAB-V8) and Overactive Bladder Questionnaire Short Form (OAB-q SF) have been assessed before and after PTNS treatment.

Mean first involuntary detrusor contraction volume (1st IDCV) on standard cystometry was 133. 2±48. 1 (24-265) mL, while it was 237. 3±43. 1 (145-390) mL after PTNS. Mean maximum cystometric capacity (MCC) on standard cystometry was 202. 2±36. 5 (115-320) mL, while it was 292. 1±50. 6 (195-395) mL after stimulation. The improvements in the 1st IDCV and MCC were statistically significant after stimulation. Mean Pdetmax at first involuntary detrusor contraction, maximal detrusor pressure at maximum cystometric capacity, PdetQmax, Qmax and PVR were statistically significant after 12 weeks stimulation. Mean parametric improvements at 12 weeks PTNS treatment from baseline included daytime frequency decreased by 5. 6 voids daily, urge incontinence decreased by 3. 1 episodes daily, urgency episodes decreased by 6. 3 episodes daily, nocturia decreased by 2. 7 voids and voided volume improved by a mean of 92. 6 ml. The change from baseline on the ICIQ-SF, OABv8 and OAB-q at 12 weeks PTNS treatment demonstrated statistically significant improvements.

These results have demonstrated that PTNS improves the LUTS and urodynamic parameters in PD patients.

Urology. 2015 Oct 02 [Epub ahead of print]

Sahin Kabay, Sibel Canbaz Kabay, Mustafa Cetiner, Emine Mestan, Mehmet Sevim, Selahattin Ayas, Hilmi Ozden, Handan Ozisik Karaman

Asc. Professor, Department of Urology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey.  Asc. Professor, Department of Neurology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey. , Asist. Professor, Department of Urology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey. , Asist. Professor, Department of Urology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey. , Research Assistant, Department of Urology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey. , Research Assistant, Department of Neurology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey. , Professor, Department of Anatomy, Eskisehir Osmangazi University Faculty of Medicine, Eskisehir, Turkey. , Professor, Department of Neurology, Canakkale 18 Mart University Faculty of Medicine, Canakkale, Turkey.

PubMed

Pelvic Health Weekly Newsletter