OBJECTIVE: To evaluate treatment success and tolerability of solifenacin among women with urinary urgency (UU) and urgency urinary incontinence (UUI).
METHODS: In a prospective, observational, multicenter pilot study in Slovenia and Croatia, 100 women with UU and UUI were enrolled between January 2011 and July 2011. Patients received 5mg of solifenacin once daily for 12weeks and completed a 3-day bladder diary, urgency questionnaire, Urogenital Distress Inventory (UDI), and Incontinence Impact Questionnaire (IIQ).
RESULTS: Overall, 91 women completed 12weeks of treatment. Severity, frequency, and bother of UU significantly had decreased at weeks 4 and 12 (P< 0.001). Improvement in UU led to an improvement in mean IIQ score: a reduction in UU frequency had the greatest impact (P=0.006). The mean treatment success rate was 74.2% (by visual analog score) and was closely related to the mean change in irritative UDI score (r=0.39; P< 0.001). Treatment success was greatest for patient perception of intensity of urgency scale (PPIUS; P=0.003), UU bother (P=0.017), and micturition frequency (P< 0.026). Dry mouth occurred in 35.2% of women at 4weeks, and 27.7% at week 12.
CONCLUSION: Solifenacin treatment was effective and well-tolerated among women with UU and UUI. All overactive bladder symptoms had improved by week 12.
Written by:
But I, Orešković S, Bratuš D, Sprem-Goldštajn M, Hlebič G. Are you the author?
Department of General Gynecology and Urogynecology, University Medical Center Maribor, Maribor, Slovenia.
Reference: Int J Gynaecol Obstet. 2013 Sep 25. pii: S0020-7292(13)00492-X.
doi: 10.1016/j.ijgo.2013.07.013
PubMed Abstract
PMID: 24135289
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