Long-term behavioral effects of chronic antimuscarinic use in spinal dysraphism: A case control study - Abstract

PURPOSE: To explore possible associations between long-term antimuscarinic use and behavioral problems in children with spinal dysraphism and neurogenic bladder dysfunction.

MATERIALS AND METHODS: After obtaining approval from the Ethical Review Board, children with spinal dysraphism (both open and closed) were recruited from two centers. At center A, antimuscarinics were prescribed in selected patients when detrusor overactivity was diagnosed. At center U, antimuscarinic agents were prescribed from birth onwards since the early 1990s. Parents of the participants were asked to fill-out a Child Behavior's Check List (CBCL). Demographics, data on level of the lesion, type of lesions and hydrocephalus/drain (and, if applicable, number of revisions) were retrieved for each patient. Cases and controls (8 boys and 8 girls per group) were matched one-to-one.

RESULTS: Data on 32 children were analyzed. Median age in the case group and control group was 10.6 years and 10.5 years, respectively (p=0.877). In each group, 9/16 had hydrocephalus with a drain. No significant difference in CBCL score for Total Problems was found between the two groups (median 52.0 vs. 59.5; p=0.39). No differences were found between the groups on any of the subdomains of the CBCL.

CONCLUSIONS: In these children with spinal dysraphism, no significant differences in behavior were found between children with and without chronic use of antimuscarinics.

Written by:
Veenboer PW, Huisman J, Chrzan RJ, Kuijper CF, Dik P, de Kort LM, de Jong TP.   Are you the author?
Department of Urology, Utrecht University Medical Center, Utrecht, The Netherlands.

Reference: J Urol. 2013 Jun 20. pii: S0022-5347(13)04647-8.
doi: 10.1016/j.juro.2013.06.036

PubMed Abstract
PMID: 23792150

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