OBJECTIVE: To investigate the association between a history of gestational diabetes mellitus (GDM) and overactive bladder (OAB) in women of premenopausal age.
DESIGN: Population-based study.
SETTING: The Swedish Twin Register.
POPULATION: In 2005, a total of 14 094 female twins born between 1959 and 1985 in the Swedish Twin Registry participated in a comprehensive survey on common exposures and complex diseases. Structured questions provided information on GDM and OAB. The present study was designed as a cross-sectional analysis including all women in the cohort having given birth before 2005 (n = 7855).
METHODS: A logistic regression model based on generalised estimating equations was used to derive odds ratios (ORs).
MAIN OUTCOME MEASURE: The association between a history of GDM and OAB was estimated using ORs with 95% confidence intervals (CIs).
RESULTS: The prevalence of OAB in women with a history of GDM was 19.1% compared with 10.7% in women without GDM. This corresponded to a two-fold increased odds of OAB in women with a history of gestational diabetes (OR 2.13, 95% CI 1.48-3.05). After adjusting the analysis for age, body mass index, parity, smoking, and diabetes mellitus, having had GDM was associated with doubled odds of OAB (OR 1.88, 95% CI 1.26-2.80).
CONCLUSIONS: A history of GDM was positively associated with OAB among women of premenopausal age. The association does not seem to be mediated by body mass index or type-I or type-II diabetes mellitus.
Written by:
Tettamanti G, Iliadou A, Pedersen N, Bellocco R, Altman D. Are you the author?
Division of Obstetrics and Gynaecology, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden.
Reference: BJOG. 2013 May 7. Epub ahead of print.
doi: 10.1111/1471-0528.12253
PubMed Abstract
PMID: 23647812
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