Stand up urgency: Is this symptom related to a urethral mechanism? - Abstract

OBJECTIVE: To study the role of women's position as a stimulus of urgency, and specifically the change of position, i.e. to stand up form a lying or sitting position. Thus, we compared clinical and urodynamics characteristics among women with overactive bladder syndrome (OAB) depending of the position which could trigger urgency.

METHODS: Thirty-eight females with complaints of urgency, without urinary infection, neurological or urological diseases, were prospectively enrolled. Patients completed a study-specific questionnaire asking about urgency and urge incontinence when in three different positions (standing up, sitting, and standing position). We named stand up urgency (SUU) an urgency, which was defined thanks to this questionnaire, according to the presence of urgency triggered by the change from sitting or lying to a standing position. All patients underwent cystometry in the standing position, urethral closure pressure measurement (MUCP) and Valsalva leak point pressure (VLPP) tests. Urodynamics characteristics were compared in the groups defined by the questionnaire.

RESULTS: SUU was associated with lower MUCP (57 vs. 77cm H(2)O; P=0.017), but not with positive VLPP or DO. Among females with SUU, those with stand up urge incontinence (SUUI) also had lower MUCP (46 vs. 73cm H(2)O; P=0.019) and more positive cough stress tests (73 vs. 13%; P=0.019). Conversely, urge incontinence in the sitting position was associated with DO (46% vs. 0%; P=0.02), but not with lower MUCP or positive VLPP.

CONCLUSION: SUU appeared to be related to impaired urethral closure mechanisms (lower MUCP), but future studies are needed to confirm this hypothesis.

Written by:
Hubeaux K, Deffieux X, Desseaux K, Verollet D, Damphousse M, Amarenco G   Are you the author?
Er6 UPMC, 75013 Paris, France; Service de neurologique et d'explorations périnéales, hôpital Tenon, groupe hospitalier universitaire Est, AP-HP, 4, rue de la Chine, 75020 Paris, France

Reference: Prog Urol. 2012 Jul;22(8):475-81
doi: 10.1016/j.purol.2012.04.011

PubMed Abstract
PMID: 22732583


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