Botulinum toxin injection for lower urinary tract dysfunction - Abstract

Botulinum toxin has been recently accepted as a novel treatment for lower urinary tract dysfunctions refractory to conventional treatment.

Review of the clinical trials in recent years, botulinum toxin type A has been widely used in the urethra or urinary bladder to treat voiding dysfunction due to detrusor sphincter dyssynergia, incontinence due to neurogenic or idiopathic detrusor overactivity, sensory disorders such as bladder hypersensitivity, overactive bladder, and interstitial cystitis/painful bladder syndrome. Intravesical botulinum toxin type A injection is effective in treatment of urinary incontinence due to detrusor overactivity in men and women, as well as in children. Currently botulinum toxin type A has also been applied to treat lower urinary tract symptoms due to benign prostatic hyperplasia in patients not suitable for surgery. This article reviewed the recent advances of botulinum toxin type A on lower urinary tract dysfunction.

Written by:
Kuo YC, Kuo HC. Are you the author?
Department of Urology, Yangming Branch of Taipei City Hospital, Taipei; Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

Reference: Int J Urol. 2012 May 9. Epub ahead of print.
doi: 10.1111/j.1442-2042.2012.03035.x

PubMed Abstract
PMID: 22571329 Overactive Bladder (OAB) Section

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