Fesoterodine in randomised clinical trials: An updated systematic clinical review of efficacy and safety - Abstract

INTRODUCTION AND HYPOTHESIS: This is a systematic review of clinical data assessing the safety, efficacy and tolerability of fesoterodine in randomised control trials (RCTs) in the treatment of overactive bladder (OAB).


METHODS: We performed a MEDLINE literature search of articles published between 2005 and 2010 regarding the efficacy and safety of fesoterodine. The US Food and Drug Administration Web site was also searched for RCTs. 

RESULTS: Two studies demonstrated significant improvement of OAB symptoms with fesoterodine compared with placebo. Two phase III studies showed both doses of fesoterodine to be more effective than placebo for most symptoms. Another phase III trial confirmed the superiority of 8 mg fesoterodine compared with tolterodine ER 4 mg. Dry mouth was the commonest side effect.

CONCLUSIONS: Fesoterodine is effective for treating OAB symptoms. Its once-daily dosing regime and the flexibility to increase the dose are appealing factors.

Written by: 
Dell'utri C, Digesu GA, Bhide A, Khullar V. Are you the author? 
Department of Urogynaecology, St. Mary's Hospital, Cambridge Wing, Praed Street, London, W1 1NY, United Kingdom.

Reference: Int Urogynecol J. 2012 Mar 13. Epub ahead of print. 
doi: 10.1007/s00192-012-1696-0 

PubMed Abstract 
PMID: 22411206