Comparisons of urodynamic effects, therapeutic efficacy and safety of solifenacin versus tolterodine for female overactive bladder syndrome - Abstract

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Pan-Chiao, Taiwan.

Departments of Obstetrics and Gynecology Urology, National Taiwan University College of Medicine and National Taiwan University Hospital, Taipei, Taiwan.

 

 

To evaluate the urodynamic effects, therapeutic efficacy and safety of solifenacin versus tolterodine treatment for women with overactive bladder syndrome.

Patients were randomized to receive either solifenacin 5 mg or tolterodine ER 4 mg once a day for 12 weeks at each four-week visit in a post-marketing study. Only women (solifenacin [n = 26] vs. tolterodine [n = 22]) were included in this subgroup analysis. Adverse events and changes of urodynamic values and clinical data were compared between the solifenacin and tolterodine groups.

The volume voided per micturition increased in the solifenacin group (n = 21) (P = 0.04). The strong desire to void and pad-test result improved in the tolterodine group (n = 21; P = 0.02 and 0.03, respectively). There were no between-group differences in changes of any urodynamic data, voiding diary values or adverse events after treatment; however, changes of heart rate differed between the two groups (P = 0.0004), especially at visit 2 (solifenacin vs. tolterodine, -4.3 vs. 3.8, P = 0.02) and visit 3 (-3.2 vs. 4.8, P = 0.03).

Both solifenacin and tolterodine had similar urodynamic effects, therapeutic efficacy and adverse events in treating women with overactive bladder syndrome; however, tolterodine had a greater effect in increasing heart rate than solifenacin.

Written by:
Hsiao SM, Chang TC, Wu WY, Chen CH, Yu HJ, Lin HH.   Are you the author?

Reference: J Obstet Gynaecol Res. 2011 Apr 19. Epub ahead of print.
doi: 10.1111/j.1447-0756.2010.01493.x

PubMed Abstract
PMID: 21501328

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