Numerous studies have shown that obesity is a risk factor for overactive bladder (OAB). However, traditional anthropometric measures, such as body mass index and waist circumference, are limited in assessing obesity, particularly central obesity. The weight-adjusted-waist index (WWI) may provide a more accurate measure of central obesity. This study aimed to explore the association between WWI and the risk of OAB. Multivariate logistic regression and restricted cubic splines were used to analyze the relationship between WWI and the risk of OAB. Subgroup interaction analyses were conducted to assess the stability of the results. Receiver operating characteristic curves were employed to evaluate the predictive ability of various anthropometric indicators for the risk of OAB. Logistic regression analysis revealed a significant positive association between WWI and the risk of OAB. After adjusting for all potential confounders, each 1-unit increase in WWI was associated with a 26% increased risk of OAB. Dose-response curve analysis showed a linear positive relationship between WWI and OAB risk. In receiver operating characteristic curve analysis, WWI demonstrated better predictive power for OAB compared to body mass index and waist circumference (area under the curve = 0.669, 95% CI = 0.662-0.677, optimal cutoff value = 11.150). This study found that an increased WWI was strongly associated with an elevated risk of OAB. WWI also proved to be a superior anthropometric indicator for assessing the risk of OAB.
Medicine. 2026 May 08 [Epub]
Xiaoyan Hu, Weixing Jing, Yiqi Huang, Tianxiao Fu, Weigang Shen, Weicheng Xiao
Department of Intensive Care Unit, Shaoxing Second Hospital, Shaoxing, Zhejiang, China., Department of Emergency, Shaoxing Second Hospital, Shaoxing, Zhejiang, China., Department of Nephrology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China., Department of Traditional Chinese Medicine, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang, China., Department of Blood Purifying Center, Shaoxing Second Hospital, Shaoxing, Zhejiang, China.