This review paper aims to comprehensively evaluate various treatment modalities for overactive bladder (OAB), focusing on their advantages, disadvantages, and impact on the quality of life (QoL) of individuals with OAB. OAB is a prevalent and often debilitating urological condition characterized by symptoms such as urgency, frequency, and urge incontinence, which significantly impair the well-being and daily activities of those affected. Treatment options for OAB are diverse, ranging from behavioral therapies, including pelvic floor exercises and bladder training, to pharmacological interventions with antimuscarinic agents and beta-3 adrenergic agonists. Additionally, advanced treatments such as neuromodulation techniques, surgical interventions, and emerging therapies like tissue engineering are explored. The review underscores the importance of personalized treatment approaches that consider patient preferences, symptom severity, and potential side effects to optimize outcomes and enhance the QoL of OAB patients. A collaborative approach between healthcare providers and patients can play an important role in discovering the most efficient treatment strategy whilst reducing the adverse effects and increasing the QoL, which shows the successful OAB management. Understanding the pros and cons of each approach is essential for informed decision-making by both patients and healthcare providers, ensuring a holistic management strategy that addresses the multifaceted nature of OAB.
Current medicinal chemistry. 2026 Mar 19 [Epub ahead of print]
Toshikee Yadav, Reshma Sahu, Shraddha Shukla, Bhanushree Gupta, Lukas Peter, Patrik Oleksak, Sangeeta Gupta, Kamil Kuca
Center for Basic Sciences, Pt Ravishankar Shukla University, Raipur, 492010, India., Center of Advanced Innovation Technologies, VSB-Technical University of Ostrava, 70800, Ostrava-Poruba, Czech Republic., Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, Hradec Kralove, Czech Republic., Govt. Shivnath Science College, Rajnandgaon, Chhattisgarh, 491441, India., Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic.