Overactive bladder (OAB) is one of the most common urinary disorders, affecting approximately 16% of the global population. It is strongly associated with obesity, diabetes, and other metabolic risk factors. The ZJU index is an innovative computational tool that integrates body mass index (BMI), fasting blood glucose (FBG), triglycerides (TG), and the alanine aminotransferase (ALT) to aspartate aminotransferase (AST) ratio, and it is highly correlated with lipid metabolism. However, the relationship between the ZJU index and OAB has not been previously explored. This cross-sectional National Health and Nutrition Examination Survey (NHANES) analysis evaluates the ZJU index as a potential OAB predictive tool, informing early intervention strategies.
This large-scale, cross-sectional study utilized data from the NHANES conducted between 2011 and 2018. Information on the medical history of renal OAB was obtained through questionnaires and recall interviews. The ZJU index was categorized into quartiles, and its association with OAB was examined using multivariate linear and logistic regression analyses, adjusted for potential confounders. The results were further visualized using restricted cubic splines (RCS) regression and threshold effect analysis. Subgroup and sensitivity analyses were also performed.
A total of 15,873 participants aged 20 years and older with complete data were included in the analysis. After controlling for confounding factors using logistic regression, a nonlinear relationship between the ZJU index and OAB was identified. Specifically, the prevalence of OAB increased with higher ZJU index levels [odds ratio (OR) =1.79, 95% confidence interval (CI): 1.57-2.04, P<0.001]. Subgroup analysis revealed that the association was significantly stronger in women (OR =1.03, 95% CI: 1.02-1.04, P<0.001), while no significant relationship was found in men (n=7,816; OR =1.01, 95% CI: 1.00-1.01, P=0.15).
Our study demonstrates that the ZJU index is significantly associated with an increased risk of OAB, particularly in women. Further research is needed to confirm these findings and explore the underlying mechanisms.
Translational andrology and urology. 2025 Dec 26 [Epub]
Jingxing Bai, Yin Huang, Shibo Jian, Jinze Li, Biao Ran, Jie Chen, Zeyu Chen, Bo Chen, Jiahao Yang, Dehong Cao, Qiang Wei, Liangren Liu
Department of Urology/Institute of Urology, West China Hospital, Sichuan University, Chengdu, China., Department of Urology, People's Hospital of Deyang City, Chengdu University of Traditional Chinese Medicine, Deyang, China.