This study aims to examine the association of systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) with the prevalence of overactive bladder (OAB).
This cross-sectional study analyzed data from 22,343 participants (≥ 20 years) in the National Health and Nutrition Examination Survey (2005-2018). We applied weighted multivariate logistic regression, restricted cubic spline (RCS) regression, subgroup, and sensitivity analyses to assess the associations between SII, NLR, and OAB.
RCS analysis revealed U-shaped relationships with inflection points at 6.13 for ln(SII) and 0.65 for ln(NLR). In the fully adjusted model, ln(SII) ≤ 6.13 showed a negative correlation with OAB (OR = 0.83; 95% CI: 0.70-0.99), while ln(SII) > 6.13 was positively correlated (OR = 1.32; 95% CI: 1.10-1.58). Similarly, ln(NLR) > 0.65 correlated positively with OAB (OR = 1.40; 95% CI: 1.16-1.71). Subgroup analyses revealed significant differences in alcohol use subgroups for ln(SII) ≤ 6.13 and ln(NLR) ≤ 0.65 (P for interaction < 0.05).
SII and NLR may serve as biomarkers for assessing OAB risk.
Lower urinary tract symptoms. 2025 Sep [Epub]
Qinglong Yang, Haolin Chen, Hanyuan Lin, Haoxian Tang, Nan Luo, Xuan Zhang, Jingtao Huang, Xuxia Sui, Qingtao Yang
Department of Urology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China., Department of Thyroid, Breast and Hernia Surgery, General Surgery, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China., Shantou University Medical College, Shantou, China., Department of Pathogenic Biology, Shantou University Medical College, Shantou, China.