Vibegron 50 mg Once Daily Improves OABSS, OAB-q SF Score in OAB Patients ≥80 Years Old in Real-World Clinical Settings and Switching from Other OAB Drugs May Reduce Residual Urine Volume.

The treatment effects of vibegron have not previously been evaluated in a prospective, non-interventional observational study of elderly Japanese patients, particularly those ≥80 years old. In addition, no reports have referred to residual urine volume in switching cases. We therefore grouped patients by condition and investigated the treatment effects of vibegron on Overactive Bladder Symptom Score (OABSS), Overactive Bladder Questionnaire Short Form (OAB-q SF), and residual urine volume in each group.

This multicenter, prospective, non-interventional, observational study consecutively enrolled OAB patients with total OABSS score ≥3 and OABSS question 3 score ≥2. Sixty-three patients from six centers were recruited. Vibegron 50 mg once daily was administered for 12 weeks as first-line monotherapy (first-line group), monotherapy switching from antimuscarinics or mirabegron due to failure of prior therapy (no washout period), or combination therapy with antimuscarinics (second-line group). OABSS, OAB-q SF, and residual urine volume were collected after 4 and 12 weeks. Adverse events were also recorded at each visit.

Of the 63 patients registered, 61 were eligible for analysis (first line, n=36; second line, n=25). The OABSS, excluding daytime frequency scores, and OAB-q SF scale showed significant improvement in all conditions. Switching from mirabegron to vibegron significantly reduced residual urine volume. No serious treatment-related adverse events were encountered.

Vibegron 50 mg once daily significantly improved OABSS and OAB-q SF even in patients ≥80 years old. Notably, switching from mirabegron to vibegron resulted in significant improvements to residual urine volume.

Research and reports in urology. 2023 May 22*** epublish ***

Takahira Kuno, Kenji Tamura, Nobutaka Shimizu, Hideo Fukuhara, Satoshi Fukata, Shingo Ashida, Takashi Karashima, Hirofumi Satake, Kohji Sawada, Ichiro Yamasaki, Fumito Komatsu, Hajime Kuroiwa, Motoaki Saito, Keiji Inoue

Department of Urology, Kochi Medical School, Kochi University, Nankoku, Japan., Department of Urology, Chikamori Hospital, Kochi, Japan., Department of Urology, Kochi Prefectural Hata Kenmin Hospital, Sukumo, Japan., Department of Urology, Kubokawa Hospital, Takaoka-gun, Japan., Department of Urology, Tosa Municipal Hospital, Tosa, Japan., Integrated Center for Advanced Medical Technologies (ICAM-Tech), Kochi Medical School, Nankoku, Japan., Department of Pharmacology, Kochi Medical School, Kochi University, Nankoku, Japan.

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