Noninvasive spinal neuromodulation mitigates symptoms of idiopathic overactive bladder.

Overactive bladder (OAB) affects 12 to 30% of the world's population. The accompanying urinary urgency, frequency and incontinence can have a profound effect on quality of life, leading to depression, social isolation, avoidance of sexual activity and loss of productivity. Conservative measures such as lifestyle modification and pelvic floor physical therapy are the first line of treatment for overactive bladder. Patients who fail these may go on to take medications, undergo neuromodulation or receive injection of botulinum toxin into the bladder wall. While effective, medications have side effects and suffer from poor adherence. Neuromodulation and botulinum toxin injection are also effective but are invasive and not acceptable to some patients.

We have developed a novel transcutaneous spinal cord neuromodulator (SCONE™,) that delivers multifrequency electrical stimulation to the spinal cord without the need for insertion or implantation of stimulating electrodes. Previously, multifrequency transcutaneous stimulation has been demonstrated to penetrate to the spinal cord and lead to motor activation of detrusor and external urethral sphincter muscles. Here, we report on eight patients with idiopathic overactive bladder, who underwent 12 weeks of SCONE™ therapy.

All patients reported statistically significant clinical improvement in multiple symptoms of overactive bladder, such as urinary urgency, frequency and urge incontinence. In addition, patients reported significant symptomatic improvements as captured by validated clinical surveys.

SCONE™ therapy represents the first of its kind therapy to treat symptoms of urgency, frequency and urge urinary incontinence in patients with OAB.

The study was listed on clinicaltrials.gov ( NCT03753750 ).

Bioelectronic medicine. 2022 Mar 23*** epublish ***

Hui Zhong, Emilie Liu, Priya Kohli, Laura Perez, V Reggie Edgerton, David Ginsberg, Parag Gad, Evgeniy Kreydin

Department of Neurobiology, University of California, Los Angeles, CA, 90095, USA., Rancho Research Institute, Rancho Los Amigos National Rehabilitation Center, Downey, CA, 90242, USA., Department of Neurobiology, University of California, Los Angeles, CA, 90095, USA. .