The clinical pharmacology of the medical treatment for overactive bladder in adults.

Overactive bladder is a prevalent symptom complex that affects the patient's quality of life. Any disruption between the neuronal micturition pathway can lead to bladder overactivity. Neurogenic causes, myogenic causes, aging, bladder outlet obstruction, sex and psychological factors are some of the factors contributing to bladder overactivity. The complaint of any symptoms of OAB, which is highly prevalent and affects overall QOL, often needs therapeutic interventions. When conservative therapy methods fail, the addition of medications is recommended. The most commonly used agents for the treatment of OAB are antimuscarinic drugs. New classes of drugs, such as beta-3 agonists, have enriched our pharmacologic armamentarium.

In this review, with special focus on oral pharmacological treatments, we discussed the definition, etiology, symptoms, diagnosis and management of OAB.

OAB is a multifactorial condition with every patient presenting with a different collection of symptoms and signs. The medical therapies should be given in conjunct with behavioral therapies. Using high or low doses, flexible doses and stopping or changing the medications are interchangeable strategies based on the level of treatment efficacy and patient satisfaction.

Expert review of clinical pharmacology. 2020 Jun 05 [Epub ahead of print]

Hadi Mostafaei, Shahrokh F Shariat, Hanieh Salehi-Pourmehr, Florian Janisch, Keiichiro Mori, Fahad Quhal, Sakineh Hajebrahimi

Department of Urology, Medical University of Vienna , Vienna, Austria., Research Center for Evidence Based Medicine, Tabriz University of Medical Sciences , Tabriz, Iran.

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