In this study, we aimed to explain the role of oxidative stress in women with overactive bladder (OAB) by investigating the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and malondialdehyde (MDA), an indicator of lipid peroxidation.
A total of 90 women were included in the study: 45 female patients diagnosed with OAB at Hopa State Hospital Urology Polyclinic and 45 healthy women without any metabolic or neurologic disease. Levels of MDA and 8-OHdG were measured in 24-hour urine samples for all subjects.
Urinary levels of MDA and 8-OHdG were significantly higher in the OAB group than in the control group (p<0.001). A significant positive correlation (p<0.001) was found between the measurements of 8-OHdG and MDA.
Oxidative stress may be important in the pathophysiology of OAB, because levels of 8-OHdG and MDA are increased. Increased levels of 8-OHdG may be due to damaged nuclear and mitochondrial DNA as a result of oxidative attacks caused by free radicals. Nevertheless, further randomized and prospective studies with larger patient populations are needed.
Investigative and clinical urology. 2018 Jun 14 [Epub]
Eda Dokumacioglu, Ozay Demiray, Ali Dokumacioglu, Arzu Sahin, Tugba Mazlum Sen, Soner Cankaya
Department of Nutrition and Dietetics, Artvin Coruh University Faculty of Healthy Sciences, Artvin, Turkey., Department of Urology, Hopa State Hospital, Artvin, Turkey., Department of Medical Biochemistry, Hopa State Hospital, Artvin, Turkey., Department of Physiology, Ordu University Faculty of Medicine, Ordu, Turkey., Department of Medical Biochemistry, Karadeniz Teknik University Faculty of Medicine, Trabzon, Turkey., Department of Biostatistics and Medical Informatics, Ordu University Faculty of Medicine, Ordu, Turkey.