Nocturia may be one of the most persistent and bothersome lower urinary tract symptoms (LUTS) in men treated for benign prostatic obstruction (BPO). This study aimed to evaluate the evolution of nocturia after endoscopic enucleation of the prostate (EEP) and identify predictors of no postoperative improvement.
We conducted a multicenter retrospective study of 120 men who underwent EEP for LUTS/BPO and nocturia evaluation using voiding diaries. Patients with isolated nocturia were not considered for surgery. Outcomes were categorized into complete remission, partial improvement, stability, or worsening.
At a median follow-up of 15 months, 45% of patients achieved complete remission of nocturia, 19% experienced partial improvement, 30% remained stable, and 6% worsened. The median time for improvement was 6 months. Cox regression analysis identified predominant overactive bladder symptoms as the only significant predictor of no response (HR 1.68; 95% CI, 1.01-2.82; p = 0.04). No significant association was found with age, body mass index, prostate volume, or cardiometabolic comorbidities.
This multicenter study highlights that while nocturia often persists after EEP, nearly two-thirds of patients experience meaningful improvement, emphasizing both the potential benefit of surgery and the multifactorial nature of the symptom.
World journal of urology. 2025 Jun 20*** epublish ***
Thibaut Long Depaquit, Christopher Aguëro, Alessandro Uleri, Marvin Jourdan, Marc Fourmarier, Bastien Gondrand-Tellier, Raphaëlle Delonca, Omar Tnibar, Arthur Peyrottes, Julien Laroche, Benoit Molimard, Cyrille Bastide, Michael Baboudjian
Department of Urology, Hôpital d'Instruction des Armées Sainte-Anne, Toulon, France. ., Department of Urology, Hôpital d'Instruction des Armées Sainte-Anne, Toulon, France., Department of Urology, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille (AP-HM), Marseille, France., Department of Urology, Centre Hospitalier du Pays d'Aix, Aix-en-Provence, France., Department of Urology, Hôpital de la Conception, AP-HM, Marseille, France., Department of Urology, Centre Hospitalier de La Ciotat, La Ciotat, France.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/40540131