Gut Microbiota and Interstitial Cystitis: Exploring the Gut-Bladder Axis Through Mendelian Randomization, Biological Annotation and Bulk RNA Sequencing - Beyond the Abstract
Butyricimonas, Coprococcus, Lactobacillales, Lentisphaerae, and Bilophila wadsworthia were positively correlated with interstitial cystitis risk, while taxa such as Desulfovibrio piger, Oscillibacter unclassified and Ruminococcus lactaris exhibited protective effects. In addition, seven hub genes (SPTBN1, PSME4, CHAC2, ERLEC1, ASB3, STAT5A, and STAT3) were identified as differentially expressed between patients with interstitial cystitis and healthy individuals. This study established a causal relationship between gut microbiota and interstitial cystitis.
In addition, the identification of host gene-microbiota association provides a new avenue to study the underlying pathogenesis of interstitial cystitis and to develop personalized treatment strategies.
Written by: Ninghan Feng, Department of Urology, Jiangnan University Medical Center, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.
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