Male infertility, often worsened by oxidative stress, remains a challenging issue that significantly impacts sperm quality.
Reactive oxygen species (ROS) are key contributors to sperm DNA damage, reduced motility, and abnormal morphology. In response to these challenges, advanced sperm processing techniques like density gradient centrifugation and magnetic-activated sperm cell sorting have been developed to optimize sperm selection and reduce ROS levels.
This commentary examines recent research on these techniques and their impact on sperm quality, highlighting their potential in the treatment of male infertility.
Journal of obstetrics and gynaecology of India. 2025 Jul 02 [Epub]
Rajajeyakumar Manivel, A S Vickram, Nidhi Sharma, Sargunadevi Sivanantham
Physiology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Deemed University, Thandalam, Chennai, Tamil Nadu 602 105 India., Biotechnology, Saveetha School of Engineering (SSE), Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Deemed University, Thandalam, Chennai, Tamil Nadu 602 105 India., Obstetrics and Gynaecology, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha Deemed University, Thandalam, Chennai, Tamil Nadu 602 105 India., Embryology, Dr. Aravind's IVF, Chennai, India.