Male infertility is a pressing health issue in Bangladesh, affecting a significant portion of the male population and necessitating investigation into its underlying molecular and hormonal mechanisms. Therefore, it is of interest to investigate the molecular and hormonal mechanisms underlying male infertility in Bangladesh, a pressing health issue affecting a significant portion of the male population. Hormonal assays and molecular biomarkers, including sperm DNA fragmentation, reactive oxygen species (ROS) and HSP70 expression, were analyzed. Infertile men showed show FSH and LH levels, reduced testosterone and elevated ROS and DNA fragmentation compared to controls. Thus, novel insights into the molecular and hormonal mechanisms contributing to male infertility in Bangladesh specifically highlight the impact of hormonal imbalance and oxidative stress.
Bioinformation. 2026 Jan 31*** epublish ***
Humaira Alam, Fahmida Zabin, Kazi Farhana Begum, Nigar Sultana, Taqik A Ibrahim
Department of Reproductive Endocrinology and Infertility, Bangladesh Medical University, Shahbag, Dhaka, Bangladesh., Department of Obstetrics and Gynaecology, Bangladesh Medical University, Shahbag, Dhaka, Bangladesh., Department of Molecular and Cellular Biology, University of Guelph, Guelph, Canada.