Men affected by substantial defects in spermatogenesis have previously been considered untreatable in nearly all cases. The advances of intracytoplasmic sperm injection (ICSI) and microdissection testicular sperm extraction (mTESE) brought the potential of treatment to a substantial proportion of men with severe infertility. Novel approaches for restoration of stem cells within the testis that has severely impaired function, and enhancement of spermatogenesis are now being actively investigated. In this issue of Fertility & Sterility, we have three Views and Reviews on these topics as well as the special topic of fertility preservation for the pre-pubertal male.
Fertility and sterility. 2025 Jun 23 [Epub ahead of print]
Peter N Schlegel
New York Mens Health Medical, 983 Park Avenue, New York, NY, 10028.