This review details the epidemiology, possible mechanisms, and risk factors associated with urogenital autonomic dysfunction in diabetes. Autonomic neuropathy in diabetes is associated with various urological complications including bladder and sexual dysfunction. Several studies have reported the high prevalence of bladder and sexual dysfunction in both men and women. The DCCT/EDIC UroEDIC study examined the association between cardiovascular autonomic neuropathy and bladder and sexual dysfunction in a large cohort of participants with type 1 diabetes and was the first to report significant associations. Future studies are needed to further evaluate the association of urogenital complications and autonomic dysfunction in diabetes.
Current diabetes reports. 2016 Dec [Epub]
Barbara H Braffett, Hunter Wessells, Aruna V Sarma
The Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD, 20852, USA. ., Department of Urology, University of Washington School of Medicine, 1959 NE Pacific St, Box 356510, Seattle, WA, 98195, USA., Department of Urology, University of Michigan, 2800 Plymouth Rd, Bldg 16, 109E, Ann Arbor, MI, 48109, USA.