Erectile dysfunction (ED) is a common occurrence and its incidence is expected to increase significantly along with the increase in various lifestyle diseases. The drug utilization for ED is very low.
Also, studies describing the prescription pattern in ED are lacking.
We conducted a retrospective cross-sectional observational study, including a drug utilization analysis, of 606 prescriptions as per the standard guidelines (WHO and STROBE).
Out of 606, 249 (41%) were from the age group of 30-39 years. Addictions were present in 388 (64%). Out of 606, 186 had urological, 154 had cardiovascular and 102 had psychological co-morbid disorders. Out of 348, 201 were prescribed Tadalafil (low dose) on a once daily basis. Out of 172, 121 were prescribed Sildenafil (high dose) on an 'as and when required' basis. Nutritional/ herbal supplements were prescribed in 126/606. The ratio of 'Prescribed Daily Dose' to 'Defined Daily Dose' of Tadalafil, Sildenafil, and Dapoxetine were 1. 1, 1. 3 and 1. 5 respectively.
Measures for de-addiction play an important role in the overall management of ED. The most common co-morbid disorders were urological, like BPH, LUTS, etc, followed by cardiovascular, psychological and diabetes. Overall, rational pharmacotherapy was observed. Tadalafil was the most commonly prescribed drug for ED. The main factor in the selection of a particular PDE5 inhibitor was its pharmacokinetics and cost. Udenafil, being the costliest, was the least prescribed. Dapoxetine was used in a significant number of individuals primarily for PE with ED. The combination of Papaverine, Chlorpromazine ± Alprostadil was used as intracavernosal injection in patients not responding to oral drugs.
Journal of clinical and diagnostic research : JCDR. 2015 Jul 01 [Epub]
Amit S Mutha, Vijay R Kulkarni, Sagar B Bhagat, Amit S Beldar, Sadiq B Patel
Assistant Professor, Department of Pharmacology, Grant Medical College & Sir JJ Hospital , Mumbai, India . , Consultant Andrologist & Microsurgeon, Department of Urology, Honorary Consultant Lokmanya Tilak Medical College & Hospital , Sion, Mumbai, India . , Junior Resident-III, Department of Pharmacology, Grant Medical College & Sir JJ Hospital , Mumbai, India . , Assistant Professor, Department of Pharmacology, Grant Medical College & Sir JJ Hospital , Mumbai, India . , Professor & Head, Department of Pharmacology, Grant Medical College & Sir JJ Hospital , Mumbai, India .