A systematic review and meta-analysis of de novo erectile dysfunction after anterior urethroplasty, "Beyond the Abstract," by Benjamin N. Breyer, MD, et al

BERKELEY, CA (UroToday.com) - Systematic review of erectile dysfunction (ED) after urethroplasty found reported rates of de novo ED ranging from 0% to 38%. In meta-analysis of 36 studies of 2 323 total patients, the incidence of de novo ED after urethroplasty was 1% (CI: 1-3%). The incidence of de novo ED was not associated with age, location of stricture, stricture length, type of repair, or history of prior failed urethroplasty procedures.

Significant heterogeneity of the studies included in this meta-analysis must be taken into account when interpreting these results. Many studies relied on patient self-reporting of ED rather than direct questioning or survey. However, based on the available evidence, urethroplasty for urethral stricture has a very low impact on long-term erectile function. Patients should also be counseled that, in many cases, de novo ED is likely due to short-term effects of surgery and has been demonstrated to resolve in most patients within 6-12 months.

We recommend standardized patient reported outcome measures for urethroplasty patients in order to best assess outcomes, including de novo ED. The existence of comorbid conditions that have an established role in ED, such as atherosclerosis or diabetes, should also be documented.

Written by:
Carissa Chu, BS; Sarah D. Blaschko, MD; and Benjamin N. Breyer, MD as part of Beyond the Abstract on UroToday.com. This initiative offers a method of publishing for the professional urology community. Authors are given an opportunity to expand on the circumstances, limitations etc... of their research by referencing the published abstract.

Department of Urology, University of California San Francisco, San Francisco, CA, USA

De novo erectile dysfunction after anterior urethroplasty: A systematic review and meta-analysis - Abstract

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