Department of Endocrinology, Hospital Universitario Dr. Peset, Valencia, Spain.
Department of Cardiology, Hospital Universitario Dr. Peset, Valencia, Spain; Research Foundation, Hospital Universitario Dr. Peset, Valencia, Spain; Department of Medicine, University of Valencia, Valencia, Spain; Department of Pharmacology and Ciberehd, University of Valencia, Valencia, Spain; Department of Physiology, University of Valencia, Valencia, Spain.
Erectile dysfunction (ED) is associated with cardiovascular disease (CVD) because it is highly prevalent among those with cardiovascular risk factors (CVRFs). Moreover, it precedes the development of CVD and is considered a subrogate marker of subclinical CVD.
The aim of this study was to evaluate the presence of ED among patients with type 2 diabetes (DM2) without macroangiopathy, and to assess the association between ED and other CVRFs, chronic diabetes complications, silent myocardial ischemia (SMI), and peripheral arterial disease (PAD).
One hundred fifty-four male patients with DM2 and without clinical evidence of CVD were included in the study. The presence of ED, PAD, SMI, chronic diabetic complications, and other CVRFs was evaluated in these patients.
Main Outcome Measures: PAD; SMI; ED; 24-hour blood pressure Holter; lipid profile; insulin resistance; testosterone; chronic inflammation; nephropathy; retinopathy; neuropathy.
Prevalence of ED was 68.2%. Patients with ED were older and characterized by DM2, systolic blood pressure (BP), retinopathy, and insulin treatment of longer duration than patients without ED, even when adjusting for age was performed. Adjusting for duration of diabetic condition revealed significant differences in age and systolic BP. Independent factors for ED were age (57.7 ± 7.5 years, relative risks [RR 1.1], P = 0.003) and duration of diabetes (9[3-15] years, RR 1.1, P = 0.006). SMI was detected in 13.6% of patients (18.1% in patients with ED vs. 4.1% in patients without ED). Asymptomatic PAD was detected in 13.2% of subjects (14.4% in patients with ED vs. 10.4% in patients without).
ED is highly prevalent in DM2, and is associated with the presence of SMI, higher systolic BP and chronic microvascular diabetic complications.
Written by:
Malpartida KG, Lozano RM, Fernández AJ, Gómez Martínez MJ, Izquierdo ES, Victor VM, Barajas MR, Cervera DS, Hernández Mijares A. Are you the author?
Reference: J Sex Med. 2011 Jun 23. Epub ahead of print.
doi: 10.1111/j.1743-6109.2011.02365.x
PubMed Abstract
PMID: 21699670
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