To evaluate the potential causal relationship between serum uric acid levels and erectile dysfunction in men, this study performed a Mendelian randomization (MR) analysis. The exposure factor was serum uric acid, and the outcome factor was erectile dysfunction. All data come from genome-wide association studies, and 2-sample MR studies are conducted based on R Studio 4.3.2 and the "TwoSampleMR" R software package. The inverse-variance weighted and MR-Egger methods are mainly used for analysis. Neither the inverse-variance weighted (Beta = 0.068; SE = 0.062; P = .274) nor the MR-Egger (Beta = 0.079; SE = 0.101; P = .436) approaches demonstrated a causal association between the 2 variables. According to this MR study, there is no causal relationship between serum uric acid levels and male erectile dysfunction, so medication to lower uric acid levels alone may not be effective in treating erectile dysfunction in patients with high serum uric acid.
Medicine. 2025 Sep 12 [Epub]
Wenyu Chi, Weihui Jia, Chengrong Zhang, Guobao Sun
Department of Urology, Affiliated Hospital of Shandong Second Medical University, Weifang, Shandong Province, China., Department of Gastroenterology, Weifang People's Hospital, Weifang, Shandong Province, China.