Association of oxidative stress with erectile dysfunction in community-dwelling men and men on dialysis.

To investigate the association between oxidative stress and erectile dysfunction (ED) in community-dwelling men and men on dialysis.

This cross-sectional study included 398 community-dwelling men and 42 men on dialysis. Oxidative stress was assessed using 8-hydroxy-2'-deoxyguanosine (8-OHdG). Univariable and multivariable logistic regression analyses were performed to evaluate the association between oxidative stress and ED.

Spearman's rank correlation test showed no significant correlation between urine 8-OHdG levels and the 5-Item International Index of Erectile Function scores in community-dwelling men (ρ = -0.005, p = 0.917) and between plasma 8-OHdG levels and the Sexual Health Inventory for Men scores in men on dialysis (ρ = 0.166, p = 0.295). In community-dwelling men, univariable and multivariable analyses revealed that urine 8-OHdG level was not significantly associated with ED (odds ratio [OR]: 1.005, 95% confidence interval [CI]: 0.884-1.144, p = 0.934; OR: 0.930, 95% CI: 0.798-1.084, p = 0.353; respectively). In men on dialysis, univariable analyses revealed that plasma 8-OHdG level was not significantly associated with severe ED (OR: 0.967, 95% CI: 0.876-1.066, p = 0.498).

Oxidative stress was not significantly associated with ED prevalence and severity in community-dwelling men and men on dialysis.

The aging male : the official journal of the International Society for the Study of the Aging Male. 2022 Dec [Epub]

Naoki Fujita, Masaki Momota, Mizuri Ishida, Takuro Iwane, Shingo Hatakeyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Kazuaki Yoshikawa, Kanemitsu Yamaya, Chikara Ohyama

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Department of Innovation Center for Health Promotion, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Department of Advanced Blood Purification Therapy, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan., Department of Urology, Mutsu General Hospital, Mutsu, Japan., Department of Urology, Oyokyo Kidney Research Institute, Hirosaki, Japan.

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