Comprehensive Perspectives for Erectile Dysfunction Pharmacotherapy: from Mechanism to Application.

In recent years, the incidence of erectile dysfunction (ED) has continued to rise worldwide. Since pharmacotherapy is still the most common and effective method for the treatment of ED at present, many methods and drugs have been designed or developed for the treatment of ED. Oral phosphodiesterase-5 inhibitors and androgen supplement therapy are currently the common therapeutics for ED; however, some patients have poor response to these drugs because of the multiple pathogenic mechanisms of ED. Researchers are trying to find other treatment ways. On the one hand, many new strategies and concepts such as targeted therapy are also integrated into clinical or preclinical research; on the other hand, some combined therapies which have synergistic effects with reduced dose of single drug and less adverse effects are also developed. This review article summarized the efficacy of the latest first-line, second-line drugs and adjuvant therapies for the treatment of ED, as well as the application of comprehensive treatments, which will help doctors to not only deeply understand the mechanism of ED but select the suitable therapeutics for those patients.

Current medicinal chemistry. 2022 Jun 13 [Epub ahead of print]

Haibao Zhang, Haomin Ren, Wenbin Song, Zhishang Yang, Guodong Zhu

Department of Urology, the First Affiliated Hospital of Xi\'an Jiaotong University, Xi\'an, P. R. of China., Department of Anesthesiology and Perioperative Medicine, the First Affiliated Hospital of Xi\'an Jiaotong University, P. R. of China.